7 research outputs found

    Resource dedication problem in a multi-project environment

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    There can be different approaches to the management of resources within the context of multi-project scheduling problems. In general, approaches to multiproject scheduling problems consider the resources as a pool shared by all projects. On the other hand, when projects are distributed geographically or sharing resources between projects is not preferred, then this resource sharing policy may not be feasible. In such cases, the resources must be dedicated to individual projects throughout the project durations. This multi-project problem environment is defined here as the resource dedication problem (RDP). RDP is defined as the optimal dedication of resource capacities to different projects within the overall limits of the resources and with the objective of minimizing a predetermined objective function. The projects involved are multi-mode resource constrained project scheduling problems with finish to start zero time lag and non-preemptive activities and limited renewable and nonrenewable resources. Here, the characterization of RDP, its mathematical formulation and two different solution methodologies are presented. The first solution approach is a genetic algorithm employing a new improvement move called combinatorial auction for RDP, which is based on preferences of projects for resources. Two different methods for calculating the projects’ preferences based on linear and Lagrangian relaxation are proposed. The second solution approach is a Lagrangian relaxation based heuristic employing subgradient optimization. Numerical studies demonstrate that the proposed approaches are powerful methods for solving this problem

    Managing and modelling general resource transfers in (multi-)project scheduling

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    Most approaches to multi-project scheduling are based on the assumption that resources can be transferred between projects without any expense in time and cost. As this assumption often is not realistic, we generalise the multi-project scheduling problem (RCMPSP) by additionally including transfer times and cost. To integrate this aspect, in a first step, we develop a framework for considering resource transfers in single and multi-project environments. It includes managerial approaches to handle resource transfers, a classification of resource transfer types and new roles that resources can take in these transfers. Afterwards, we define the multi-project scheduling problem with transfer times (RCMPSPTT) and formulate it in a basic and an extended version as integer linear programmes. Eventually, it is supplemented for the first time by cost considerations and introduced as resource constrained multi-project scheduling problem with transfer times and cost (RCMPSPTTC). Computational experiments compare the presented managerial approaches and prove the necessity of explicitly considering transfer times in project scheduling. Moreover, the experiments evaluate the presented MIP models and show that specialised solution procedures are vital.project scheduling - combinatorial optimization - mathematical model - transfer times - transfer cost - setup - resource flow

    Triple-negative breast cancer: new treatment strategies in the era of precision medicine

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    Combination cancer immunotherapy and new immunomodulatory targets

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